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The human articulating joints, particularly those of the lower limbs, are able to last a lifetime, with good care, and good luck. All-too-often, however, either through traumatic injury or a simple over-use, the cartilage surface of the joint starts a slow and steady decay. This decay, often described as abnormal turnover in which the destruction of cartilage exceeds the production, eventually leads to painful joints and a loss of mobility. There are a wide range of treatments in active use…